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haemophilus test medium htm broth
Bd Becton Dickinson Vacutainer Systems Preanalytic
Summary: The Haemophilus test medium HTM broth is used for susceptibility testing of various bacterial strains. It is primarily used in clinical microbiology to determine antimicrobial resistance. Key evidence highlights its use in testing Eikenella corrodens and Neisseria meningitidis.
FDA Clearance Information
Pathway
510K
Number
K903425 ↗
Decision Date
August 22, 1990
Product Code
JSO
Device Class
Class 2
Evidence
419 studies
The Haemophilus test medium HTM broth was cleared by the FDA via the 510(k) pathway on August 22, 1990. It is manufactured by Bd Becton Dickinson Vacutainer Systems Preanalytic and classified as a Class 2 device.
What It Is
The Haemophilus test medium HTM broth is a culture medium designed for the susceptibility testing of bacteria, particularly Haemophilus species. It is used in clinical laboratories to assess the minimum inhibitory concentrations (MICs) of antimicrobial agents against bacterial isolates.
Clinical Applications
This device is commonly used in clinical microbiology laboratories for the susceptibility testing of bacterial pathogens such as Eikenella corrodens and Neisseria meningitidis. It provides a practical solution for determining antimicrobial resistance in various clinical scenarios.
Evidence Summary
The available literature includes 10 peer-reviewed studies, with research conducted from 1996 to 1998. These studies encompass various methodologies, including broth microdilution and agar dilution methods, highlighting the device's application in antimicrobial susceptibility testing.
Reported Outcomes
Published studies report that the Haemophilus test medium HTM broth is effective in determining the susceptibility of bacterial strains such as Eikenella corrodens and Neisseria meningitidis. The broth microdilution method using HTM showed high agreement with traditional methods in determining MICs for various antimicrobial agents.
Safety Profile
Reported complications include poor growth in a small percentage of Neisseria meningitidis strains when using HTM, as noted in one study. However, no significant adverse events were reported in the literature reviewed.
Evidence Limitations
The evidence is limited by the small sample sizes and the specific bacterial strains tested. Further research is needed to validate the HTM broth's efficacy across a broader range of pathogens and clinical settings.
Linked Studies (20)
PubMed • 2025
Onyx Liquid Embolic Agent: Basic Knowledge for Its Use in Interventional Neuroradiology.
Journal of neuroendovascular therapy
RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2025
Performance evaluation of quantitative hemoglobin A2 and fetal hemoglobin testing using commercially lyophilized vs. in-house whole blood controls in Chinese clinical laboratories: a 12-year analysis of National External Quality Assessment Data.
Clinical chemistry and laboratory medicine
RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2025
Clinical progress note: Haemophilus influenzae type b.
Journal of hospital medicine
RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2025
Pilot study of social media promotion of home-based self-testing for syphilis.
Sexually transmitted diseases
RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2025
Clinical development and performance of the First to Know Syphilis Self-Test for over-the-counter usage: a de novo rapid test for treponemal antibody.
Journal of clinical microbiology
View Source →
PubMed • 2025
Implementation of an Opt-Out and Rapid Point-of-Care Syphilis Testing Program for Pregnant Patients Presenting to the Emergency Department.
Sexually transmitted diseases
RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2025
Evaluation of Rapid Syphilis Testing Using the Syphilis Health Check in Florida, 2015-2016.
Florida public health review
View Source →
PubMed • 2025
Multiplex droplet digital PCR for the detection and quantitation of Streptococcus pneumoniae, Mycoplasma pneumoniae, and Haemophilus influenzae.
Frontiers in cellular and infection microbiology
RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2025
Palm Multidiagnostic of Mycoplasma pneumoniae, Chlamydia pneumoniae, Haemophilus influenzae, and Streptococcus pneumoniae Using One-Tube CRISPR/Cas12a.
Transboundary and emerging diseases
View Source →
PubMed • 2025
Tp40: a new potential prognostic and diagnostic marker for syphilis.
Microbiology spectrum
View Source →
PubMed • 2025
Serotonin sets up neutrophil extracellular traps to promote neuroendocrine prostate cancer metastasis in the liver.
The Journal of clinical investigation
RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2025
Application value of Philips Ingenuity TF PET/CT scanner imaging agent FAP in evaluating renal fibrosis.
Hellenic journal of nuclear medicine
RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2025
Message from Dr. Philippe T. Georgel, Guest Editor for the Marshall University Collection, Brad D. Smith, President of Marshall University, and Dr. Anivandan Mukherjee, Provost of Marshall University.
Biochemistry and cell biology = Biochimie et biologie cellulaire
View Source →
PubMed • 2025
Improved patient comfort and procedural efficiency using chlorhexidine-coated hydrophilic urethral catheters: a randomized controlled trial.
Journal of Yeungnam medical science
RCT View Source →
PubMed • 2025
pTx-Pulseq in hybrid sequences: Accessible and advanced hybrid open-source MRI sequences on Philips scanners.
Magnetic resonance in medicine
RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2025
Comparative connectomics of Drosophila descending and ascending neurons.
Nature
RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2025
Hydrophilic-coated sheaths for reducing radial artery spasm during transradial procedures: A systematic review and meta-analysis.
Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
View Source →
PubMed • 2025
History of antineutrophil cytoplasmic autoantibodies : Milestones in rheumatology.
Zeitschrift fur Rheumatologie
View Source →
PubMed • 2025
A Hydrophilic Polyurethane Foam Containing Nigella sativa Oil as a Wound Dressing.
BioMed research international
RCT|prospective|retrospective|case Series|other View Source →Frequently Asked Questions
What are the clinical indications for Haemophilus test medium HTM broth?
The clinical indications include susceptibility testing of bacterial pathogens such as Haemophilus species, Eikenella corrodens, and Neisseria meningitidis.
What outcomes have been reported in clinical studies?
Studies have reported high agreement in MIC determination between HTM broth and traditional methods for various antimicrobial agents.
What complications have been reported?
Safety data indicate poor growth in a small percentage of Neisseria meningitidis strains, but no significant adverse events have been reported.
Disclaimer: This page compiles publicly available regulatory and published clinical evidence for educational reference.
It does not constitute medical advice, product endorsement, or a recommendation for clinical use.
Always consult manufacturer documentation and clinical judgment for patient care decisions.