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philips multileaf collimator mlc
Philips Medical Systems
Summary: The Philips Multileaf Collimator (MLC) is a device used in radiation therapy to shape the radiation beam. It is primarily used in intensity-modulated radiation therapy (IMRT) and stereotactic radiosurgery (SRS). Key evidence highlights its impact on dosimetric accuracy and delivery robustness.
FDA Clearance Information
Pathway
510K
Number
K904124 ↗
Decision Date
January 30, 1991
Product Code
IXI
Device Class
Class 2
Evidence
419 studies
The Philips Multileaf Collimator MLC was cleared via the FDA 510(k) pathway on January 30, 1991. It is manufactured by Philips Medical Systems and is classified as a Class 2 device.
What It Is
The Philips Multileaf Collimator (MLC) is a device used in radiation therapy to modulate the shape and intensity of the radiation beam. It is designed to improve the precision of radiation delivery, particularly in techniques like IMRT and SRS, by using multiple leaves to conform the beam to the target shape.
Clinical Applications
The Philips MLC is commonly used in clinical scenarios requiring precise radiation delivery, such as in the treatment of tumors located near critical structures. It is particularly useful in IMRT and SRS for targeting complex tumor shapes while minimizing exposure to surrounding healthy tissue.
Evidence Summary
The available literature includes 10 studies, comprising various study types such as RCTs, prospective, and retrospective studies. The studies span from 1999 to 2024, providing insights into the device's performance and clinical applications.
Reported Outcomes
Published studies report that the Philips MLC contributes to improved dosimetric accuracy in IMRT and robustness in SRS delivery. The device's configuration parameters significantly impact the precision of radiation dose calculations. Studies also highlight its role in minimizing end leaf leakage and the tongue and groove effect.
Safety Profile
Reported complications include potential underdosing due to the tongue and groove effect and end leaf leakage, which can affect treatment accuracy. These issues are associated with the device's design and require careful configuration and monitoring during use.
Evidence Limitations
The evidence is limited by the variability in study designs and the focus on specific technical aspects of the MLC. Further research is needed to explore long-term clinical outcomes and to optimize device settings for different clinical scenarios.
Linked Studies (20)
PubMed • 2025
Onyx Liquid Embolic Agent: Basic Knowledge for Its Use in Interventional Neuroradiology.
Journal of neuroendovascular therapy
RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2025
Performance evaluation of quantitative hemoglobin A2 and fetal hemoglobin testing using commercially lyophilized vs. in-house whole blood controls in Chinese clinical laboratories: a 12-year analysis of National External Quality Assessment Data.
Clinical chemistry and laboratory medicine
RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2025
Clinical progress note: Haemophilus influenzae type b.
Journal of hospital medicine
RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2025
Pilot study of social media promotion of home-based self-testing for syphilis.
Sexually transmitted diseases
RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2025
Clinical development and performance of the First to Know Syphilis Self-Test for over-the-counter usage: a de novo rapid test for treponemal antibody.
Journal of clinical microbiology
View Source →
PubMed • 2025
Implementation of an Opt-Out and Rapid Point-of-Care Syphilis Testing Program for Pregnant Patients Presenting to the Emergency Department.
Sexually transmitted diseases
RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2025
Evaluation of Rapid Syphilis Testing Using the Syphilis Health Check in Florida, 2015-2016.
Florida public health review
View Source →
PubMed • 2025
Multiplex droplet digital PCR for the detection and quantitation of Streptococcus pneumoniae, Mycoplasma pneumoniae, and Haemophilus influenzae.
Frontiers in cellular and infection microbiology
RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2025
Palm Multidiagnostic of Mycoplasma pneumoniae, Chlamydia pneumoniae, Haemophilus influenzae, and Streptococcus pneumoniae Using One-Tube CRISPR/Cas12a.
Transboundary and emerging diseases
View Source →
PubMed • 2025
Tp40: a new potential prognostic and diagnostic marker for syphilis.
Microbiology spectrum
View Source →
PubMed • 2025
Serotonin sets up neutrophil extracellular traps to promote neuroendocrine prostate cancer metastasis in the liver.
The Journal of clinical investigation
RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2025
Application value of Philips Ingenuity TF PET/CT scanner imaging agent FAP in evaluating renal fibrosis.
Hellenic journal of nuclear medicine
RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2025
Message from Dr. Philippe T. Georgel, Guest Editor for the Marshall University Collection, Brad D. Smith, President of Marshall University, and Dr. Anivandan Mukherjee, Provost of Marshall University.
Biochemistry and cell biology = Biochimie et biologie cellulaire
View Source →
PubMed • 2025
Improved patient comfort and procedural efficiency using chlorhexidine-coated hydrophilic urethral catheters: a randomized controlled trial.
Journal of Yeungnam medical science
RCT View Source →
PubMed • 2025
pTx-Pulseq in hybrid sequences: Accessible and advanced hybrid open-source MRI sequences on Philips scanners.
Magnetic resonance in medicine
RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2025
Comparative connectomics of Drosophila descending and ascending neurons.
Nature
RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2025
Hydrophilic-coated sheaths for reducing radial artery spasm during transradial procedures: A systematic review and meta-analysis.
Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
View Source →
PubMed • 2025
History of antineutrophil cytoplasmic autoantibodies : Milestones in rheumatology.
Zeitschrift fur Rheumatologie
View Source →
PubMed • 2025
A Hydrophilic Polyurethane Foam Containing Nigella sativa Oil as a Wound Dressing.
BioMed research international
RCT|prospective|retrospective|case Series|other View Source →Frequently Asked Questions
What are the clinical indications for Philips Multileaf Collimator MLC?
The Philips MLC is indicated for use in radiation therapy, particularly in IMRT and SRS, to shape and modulate the radiation beam for precise targeting of tumors.
What outcomes have been reported in clinical studies?
Studies report improved dosimetric accuracy and delivery robustness in IMRT and SRS, with significant impact from configuration parameters on dose calculations.
What complications have been reported?
Safety data indicate potential underdosing due to the tongue and groove effect and end leaf leakage, necessitating careful device configuration and monitoring.
Disclaimer: This page compiles publicly available regulatory and published clinical evidence for educational reference.
It does not constitute medical advice, product endorsement, or a recommendation for clinical use.
Always consult manufacturer documentation and clinical judgment for patient care decisions.