LC Bead Microspheres Bead Block Compressible Microspheres

FDA-Cleared Indications

• Embolization of blood vessels when vascular occlusion is clinically indicated.
• Use as an embolic agent in transarterial procedures for selected liver tumors, including hepatocellular carcinoma, according to the applicable product labeling.

Clinical Applications

• Transarterial embolization of selected unresectable hepatocellular carcinomas.
• Embolization of tumor-feeding arteries in the liver.
• Standalone embolization to reduce or stop blood flow to a target lesion.
• Delivery of chemotherapy during transarterial chemoembolization when used with an appropriate drug and under the applicable labeling.

Reported off-label uses

• Embolization of other hypervascular liver tumors or metastases.
• Embolization of selected extrahepatic tumors or vascular malformations when clinically appropriate.
• Treatment of selected bleeding or vascular-flow conditions using microsphere embolization techniques.

Off-label use: these uses are reported in practice or the literature but are not part of the FDA-cleared indications. Physicians may use a cleared device off-label based on their medical judgment; the manufacturer may not promote off-label uses.

Practical Considerations

• Microsphere size selection depends on the target vessel, tumor vascularity, desired level of occlusion, and risk of non-target embolization.
• The beads are delivered through a compatible angiographic catheter under fluoroscopic or other appropriate imaging guidance; catheter size and embolic compatibility must be confirmed before use.
• Proper suspension and gentle handling are important because aggregation, settling, or excessive compression can affect delivery.
• Contraindications and precautions include uncontrolled infection, non-target arterial pathways, significant uncorrectable coagulopathy, and hypersensitivity to the product or its components, according to the current instructions for use.
• MRI safety and conditional use depend on the complete treated system, including any radiopaque markers, coils, stents, catheters, or drug components; review the current manufacturer labeling and the patient's other implanted devices.