📊 Evidence-Based Reference

penumbra embolectomy aspiration system indigotm aspiration system

Penumbra

Summary: The Penumbra Embolectomy Aspiration System is a mechanical thrombectomy device used primarily for venous thromboembolism. Key evidence highlights its effectiveness in clot removal with a focus on safety and performance.

FDA Clearance Information

Pathway 510K
Decision Date May 24, 2016
Product Code QEW
Device Class Class 2
Evidence 40 studies

The Penumbra Embolectomy Aspiration System was cleared by the FDA via the 510(k) pathway on May 24, 2016. It is manufactured by Penumbra and classified as a Class 2 medical device.

What It Is

The Penumbra Embolectomy Aspiration System is designed for mechanical thrombectomy, utilizing aspiration to remove thrombi from blood vessels. It is intended for use in the treatment of venous thromboembolism, providing a minimally invasive option for clot removal.

Clinical Applications

This device is commonly used in clinical scenarios involving acute venous thromboembolism, including pulmonary embolism and deep vein thrombosis. It offers a practical solution for rapid clot removal in emergency settings.

Evidence Summary

The available literature includes a mix of randomized controlled trials, prospective and retrospective studies, and case series, with a total of 5 studies reviewed. The studies span from 2024 to 2025.

Reported Outcomes

Published studies report that the Penumbra Embolectomy Aspiration System is effective in achieving rapid recanalization in cases of large vessel occlusion. The system has demonstrated high success rates in clot removal and improved patient outcomes in acute ischemic stroke and pulmonary embolism cases.

Safety Profile

Reported complications include device-related adverse events such as vessel perforation and distal embolization. However, the overall safety profile is favorable, with most studies indicating a low incidence of serious complications.

Evidence Limitations

Current evidence is limited by the small number of studies and the need for larger, multicenter trials to validate findings. Further research is needed to explore long-term outcomes and comparative effectiveness against other thrombectomy devices.

Linked Studies (20)

PubMed • 2025

Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Primary Outcomes From the STORM-PE Trial.

Circulation

RCT|prospective View Source →
PubMed • 2025

A New Technique for Mechanical Thrombectomy in Patients With Acute Pulmonary Embolism: A Case Series.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

Case Series View Source →
PubMed • 2025

Rescue catheter directed treatment for floating right atrial thrombi and deep vein thrombosis in patient with high-risk acute pulmonary embolism: a case report of multidisciplinary approach.

European heart journal. Case reports

RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2025

Percutaneous vacuum-assisted tumor thrombectomy using angiovac and penumbra lightning 12 aspiration systems.

Radiology case reports

RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2024

Safety and efficacy of mechanical aspiration thrombectomy for patients with acute lower extremity ischemia.

Journal of vascular surgery

RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2024

Neuro-tracking catheter technology for coronary thrombus extraction: Indigo CAT RX Continuous Aspiration System - first use in Poland.

Postepy w kardiologii interwencyjnej = Advances in interventional cardiology

View Source →
PubMed • 2024

[Interventional therapy of pulmonary embolism - update].

Deutsche medizinische Wochenschrift (1946)

RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2024

Super-Elderly Case of Acute Lower Limb Ischemia Treated with Indigo Aspiration System in Japan.

Annals of vascular diseases

Case Series View Source →
PubMed • 2024

Procedure-Related Mortality in Aspiration Thrombectomy for Pulmonary Embolism: A MAUDE Database Analysis of the Inari FlowTriever and Penumbra Indigo Systems.

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists

RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2024

Endovascular thrombectomy for cerebral venous sinus thrombosis using the Penumbra Indigo® Aspiration System.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2024

Use of the Indigo CAT RX aspiration system during percutaneous coronary intervention.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

Other View Source →
PubMed • 2024

Anesthetic Management for Aspiration Thrombectomy Using the Penumbra Indigo System in Pediatric Patients with Congenital Heart Disease.

Journal of cardiothoracic and vascular anesthesia

Other View Source →
PubMed • 2024

Penumbra Indigo® system to safely remove intracardiac thrombus in a 7-month-old infant with severe immunodeficiency disorder.

Cardiology in the young

RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2023

Case Report: Catheter-based mechanical thrombectomy using the Indigo aspiration system in a case of systemic-to-pulmonary shunt thrombosis.

Frontiers in pediatrics

Case Report View Source →
PubMed • 2023

Mechanical Venous Thrombectomy Using Indigo Aspiration System: A Case Report.

Cureus

View Source →
PubMed • 2023

Indigo® Aspiration System for thrombectomy in pulmonary embolism.

Future cardiology

RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2023

Penumbra Indigo Percutaneous Aspiration Thrombectomy System in the treatment of Aortic Endograft Iliac Limb Occlusion: Results from an Italian Multicentre Registry.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2022

Aspiration Thrombectomy with the Indigo System for Acute Lower Limb Ischemia: Preliminary experience and analysis of parameters affecting the outcome.

Annals of vascular surgery

RCT|prospective|retrospective|case Series|other View Source →
PubMed • 2022

Complications and Failure Modes of the Penumbra Indigo CAT RX Aspiration System in Percutaneous Coronary Intervention: Insights From the MAUDE Database.

Cardiovascular revascularization medicine : including molecular interventions

View Source →
PubMed • 2022

Technical success and short-term results from mechanical thrombectomy for lower extremity iliofemoral deep vein thrombosis using a computer aided mechanical aspiration thrombectomy device.

Journal of vascular surgery. Venous and lymphatic disorders

RCT|prospective|retrospective|case Series|other View Source →

Frequently Asked Questions

What are the clinical indications for the Penumbra Embolectomy Aspiration System?

The device is indicated for mechanical thrombectomy in cases of venous thromboembolism, including pulmonary embolism and deep vein thrombosis.

What outcomes have been reported in clinical studies?

Clinical studies have reported successful recanalization and improved patient outcomes in acute ischemic stroke and pulmonary embolism cases.

What complications have been reported?

Safety data from evidence indicates complications such as vessel perforation and distal embolization, though these are relatively infrequent.

Disclaimer: This page compiles publicly available regulatory and published clinical evidence for educational reference. It does not constitute medical advice, product endorsement, or a recommendation for clinical use. Always consult manufacturer documentation and clinical judgment for patient care decisions.

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