What are the subacute MRI findings in profound perinatal hypoxic-ischemic injury, specifically in the deep gray matter and perirolandic cortex?

In subacute profound perinatal hypoxic-ischemic injury, MRI may show variable T1 and T2 signal intensities in the deep gray matter, such as the basal ganglia and thalami. The perirolandic cortex often demonstrates high T1 and low T2 signal intensities, indicative of cortical laminar necrosis. Key diagnostic features include diffusion restriction in affected areas. Clinically, it is important to differentiate these findings from metabolic disorders or infections, which can present similarly.